Author  
Place of duty  
Title   대장암의 다발성 간전이에 대한 간동맥 항암제주사요법 ( Hepatic Intraarterial Chemotherapy in Unresectable Hapatic Metastases of Colorectal Cancer )
Publicationinfo   1997 Jan; 029(02): 227-235.
Key_word   Regional chemotherapy, Colorectal cancer, Hepatic metastasis
Full-Text  
Abstract   Purpose: Unresectable hepatic metastases of colorectal cancer does not seem to be amenable to the various treatment modalities. We modified hepatic intraarterial chemotherapy by different installation of port and regimen. Materials and Methods: Between July 1989 to December 1995, 27 patients of colorectal cancer with unresectable liver metastases were randomly allocated into either hepatic intraarterial(HA, 11 patients) or systemic intravenous(IV, 16 patients) chemotherapy after primary tumor resection. Chemo-port was installed with preservation of hepatic arterial flow. One cycle of HA regimen included 5-fluorouracil(5-FU) and mitomycin-C(MMC) with or without leucovorin(LV) for 14 days every month. The IV regimen included 5-FU and LV for 5 days every month. Both HA and IV chemotherapy were continued from 6 to 12 cycles. Results: The response exceeding partial remission was experienced in six patients(55%) among 11 patients in the HA group, while only two(13%) patients showed response among sixteen patients in the IV group. One year survival was not different between two groups. Although lethal toxicity was not found, patients showed marked increase of the perforrnance scale(ECOG) in both groups. Conclusion: Although survival benefit was not prominent, higher response rate with tolerable complication was found in the HA group. Prudent selection of effective drugs and combination of systemic chemotherapy are needed to improve the survival with minimal complication.
저 자   김진천(Jin Cheon Kim),이한일(Han Il Lee),유창식(Chang Sik Yoo),정희원(Hee Won Chung),김상위(Sang Wi Kim),이정신(Sin Jung Lee),박건춘(Kun Choon Park)